Publications

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• Dombrovski, M., Peek, M. Y., Park, J. Y., Vaccari, A., Sumathipala, M., Morrow, C., ... Zipursky, S.L. and Card, G. M. (2023). Synaptic gradients transform object location to action. Nature, 1-9. Epub 2023 Jan 4. DOI: 10.1038/s41586-022-05562-8
• Jain, S. and Zipursky, S.L., 2022, May. Temporal control of neuronal wiring. In Seminars in Cell & Developmental Biology. Academic Press. DOI: 10.1016/j.semcdb.2022.05.012
• Xu S, Sergeeva AP, Katsamba PS, Mannepalli S, Bahna F, Bimela J, Zipursky SL, Shapiro L, Honig B, Zinn K. Cell Rep. 2022 Apr 5;39(1):110618. doi: 10.1016/j.celrep.2022.110618.  Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules.
• Jain S, Lin Y, Kurmangaliyev YZ, Valdes-Aleman J, LoCascio SA, Mirshahidi P, Parrington B, Zipursky SL. Nature. 2022 Mar;603(7899):112-118. doi: 10.1038/s41586-022-04418-5. Epub 2022 Feb 23. A global timing mechanism regulates cell-type-specific wiring programmes.
• Cheng, S., Butrus, S., Xu, V., Tan, L., Sagireddy, S., Trachtenberg, J. T., Shekhar, K., and Zipursky, S.L. (2021). Vision-dependent specification of cell types and function in the developing cortex. bioRxiv 2021.08.10.455824
• Xu, S., Sergeeva, Katsamba, P.S., Mannepalli, S., Bahna, F., Bimeli, J, Zipursky, S.L., Shapiro, L., Honig, B., and Zinn, K. (2021). Affinity requirements for control of synaptic targeting and neuronal cell survival by heterphilic IgSF cell adhesion molecules. bioRxiv 2021.02.16.431482
• Tan, L., Ringach, D.L., Zipursky, S.L., and Trachtenberg, J.T. (2021). Vision is required for the formation of binocular neurons prior to the classical critical period. Current Biology 31, 4305-4313
• Sanes, J.R. and Zipursky, S.L. (2020). Synaptic specificity, recognition molecules, and assembly of neural circuits. Cell 181, 536-556.
• Akin, O. and Zipursky, S.L. (2020). Activity regulates brain development in the fly. Curr Opin Genet Dev 65, 8-13.
• Jain, S., Lin, Y., Kurmangaliyev, Mirshahidi, P. Parrington, B. and Zipursky, S. L.(2020). A global temporal genetic program for neural circuit formation. bioRxiv 2020.09.18.304410
• Tan, L., Tring, E., Ringach, D.L., Zipursky, S.L. and Trachtenberg, J.T. (2020). Vision changes the cellular composition of binocular circuitry during the critical period. Neuron 108, 735-747.
• Kurmangaliyev, Y.Z., Yoo, J., Valdes-Aleman, J., Sanfilippo, P. and Zipursky, S.L. (2020). Transcriptional programs of circuit assembly in the Drosophila visual system. Neuron 108, 1045-1057.
• Veldman, M.B., Park. C.S., Eyerman, C.M, Zhang, J.Y., … Zipursky, S.L, Zeng, H., Dong, H., and Yang, X.W. (2020). Brainwide genetic sparse cell labeling to illuminate the morphology of neurons and glia with cre-dependent MORF mice. Neuron 108, 111-127.
• Kurmangaliyev, Y.Z., Yoo, J., LoCascio, S.A. and Zipursky, S. L. (2019). Modular transcriptional programs define neuron subtype-specific connectivity. eLife 8:e50822 (doi:10.7554/eLife.50822
• Akin, O., Bajar, B., Keles, M.F., Frye, M.A., and Zipursky, S.L. Cell-type-specific patterned stimulus-independent neuronal activity in the Drosophila visual system during synapse formation. (2019). Neuron 101, 894-904.
• Xu, S., Xiao, Q., Tan, L., Kauffman, J., Cosmanescu, F., Sergeeva, A., Honig, B., Shapiro, L., and Zipursky, S. L. * Interactions between the Ig-Superfamily Proteins DIP-α and Dpr6/10 Regulate Assembly of Neural Circuits, Neuron 100, 1385-1400 .
• Cosmanescu, F., Katsamba, P.S., Sergeeva, A.P.m Ahlsen, G., Patel, S.D., Brewer, J.J., Tan, Tan, L., Xu, S., Xiao, Q., Nagarkar-Jaisewal, S., Bellen, H., Zipursky, S. L., Honig, B., and Shapiro, L. (2018). Neuron sub-type specific expression, interaction affinities, and specificity determinants of DIP/Dpr cell recognition proteins, Neuron 100, 1369-1384 .
• Sarin S, Zuniga-Sanchez, E. Kurmanaliyev, Y., Cousins, H., Patel, M., Hernandez, J., Zhang, KX, Samuel, M, Morey, M., Sanes, J.R., and Zipursky, S.L (2017). Role of Wnt signaling in retinal neuropil development: Anaylsis via RNA-seq and in vivo somatic CRISPR mutagenesis, Neuron 98, 343-353.
• Akin, O. and Zipursky, S. (2016). Frazzled promotes growth cone attachment at the source of a Netrin gradient in the Drosophila visual system. eLife 5: e20762.
• Zhang, K.X., Tan, L., Pellegrini, M., Zipursky, S. L.* and McEwen, J.M. (2016). Rapid changes in the translatome during the conversion of growth cones to synaptic terminals, Cell Reports, 14, 1258-1271 (*, corresponding authors)
• Tadros W, Xu S, Akin O, Yi CH, Shin GJ, Millard SS, Zipursky SL. Dscam Proteins Direct Dendritic Targeting through Adhesion. Neuron. 2016 Feb 3;89(3):480-93.
• Zhang KX, Tan L, Pellegrini M, Zipursky SL, McEwen JM. Rapid Changes in the Translatome during the Conversion of Growth Cones to Synaptic Terminals. Cell Rep. 2016 Feb 9;14(5):1258-71.
• Tan L, Zhang KX, Pecot MY, Nagarkar-Jaiswal S, Lee PT, Takemura SY, McEwen JM, Nern A, Xu S, Tadros W, Chen Z, Zinn K, Bellen HJ, Morey M, Zipursky SL. Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila. Cell. 2015 Dec 17;163(7):1756-69.
• Pecot MY, Chen Y, Akin O, Chen Z, Tsui CY, Zipursky SL. Sequential axon-derived signals couple target survival and layer specificity in the Drosophila visual system. Neuron. 2014 Apr 16;82(2):320-33.
• Chen Y, Akin O, Nern A, Tsui CY, Pecot MY, Zipursky SL. Cell-type-specific labeling of synapses in vivo through synaptic tagging with recombination. Neuron. 2014 Jan 22;81(2):280-93.
• Miura SK, Martins A, Zhang KX, Graveley BR, Zipursky SL. Probabilistic splicing of Dscam1 establishes identity at the level of single neurons. Cell. 2013 Nov 21;155(5):1166-77.
• Zipursky SL, Grueber WB. The molecular basis of self-avoidance. Annu Rev Neurosci. 2013 Jul 8;36:547-68.
• Pecot MY, Tadros W, Nern A, Bader M, Chen Y, Zipursky SL. Multiple interactions control synaptic layer specificity in the Drosophila visual system. Neuron. 2013 Jan 23;77(2):299-310.
• Wu W, Ahlsen G, Baker D, Shapiro L, Zipursky SL. Complementary chimeric isoforms reveal Dscam1 binding specificity in vivo. Neuron. 2012 Apr 26;74(2):261-8
• Pappu KS, Morey M, Nern A, Spitzweck B, Dickson BJ, Zipursky SL. Robo-3--mediated repulsive interactions guide R8 axons during Drosophila visual system development. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7571-6.
• Zipursky SL, Sanes JR. Chemoaffinity revisited: dscams, protocadherins, and neural circuit assembly. Cell. 2010 Oct 29;143(3):343-53.
• Millard SS, Lu Z, Zipursky SL, Meinertzhagen IA. Drosophila dscam proteins regulate postsynaptic specificity at multiple-contact synapses. Neuron. 2010 Sep 9;67(5):761-8.
• Sanes JR, Zipursky SL. Design principles of insect and vertebrate visual systems. Neuron. 2010 Apr 15;66(1):15-36. doi: 10.1016/j.neuron.2010.01.018. Review.
• Hattori D, Chen Y, Matthews BJ, Salwinski L, Sabatti C, Grueber WB, Zipursky SL. Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms. Nature. 2009 Oct 1;461(7264):644-8.
• Morey M, Yee SK, Herman T, Nern A, Blanco E, Zipursky SL. Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons. Nature. 2008 Dec 11;456(7223):795-9.
• Hattori D, Millard SS, Wojtowicz WM, Zipursky SL. Dscam-mediated cell recognition regulates neural circuit formation. Annu Rev Cell Dev Biol. 2008;24:597-620.
• Bharucha KN, Tarr P, Zipursky SL. A glucagon-like endocrine pathway in Drosophila modulates both lipid and carbohydrate homeostasis. J Exp Biol. 2008 Oct;211(Pt 19):3103-10.
• Sawaya MR, Wojtowicz WM, Andre I, Qian B, Wu W, Baker D, Eisenberg D, Zipursky SL. A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms. Cell. 2008 Sep 19;134(6):1007-18.
• Millard SS, Zipursky SL. Dscam-mediated repulsion controls tiling and self-avoidance. Curr Opin Neurobiol. 2008 Feb;18(1):84-9.
• Nern A, Zhu Y, Zipursky SL. Local N-cadherin interactions mediate distinct steps in the targeting of lamina neurons. Neuron. 2008 Apr 10;58(1):34-41.
• Cayirlioglu P, Kadow IG, Zhan X, Okamura K, Suh GS, Gunning D, Lai EC, Zipursky SL. Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems. Science. 2008 Feb 29;319(5867):1256-60.
• Ting CY, Herman T, Yonekura S, Gao S, Wang J, Serpe M, O'Connor MB, Zipursky SL, Lee CH. Tiling of r7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion. Neuron. 2007 Dec 6;56(5):793-806.
• Wojtowicz WM, Wu W, Andre I, Qian B, Baker D, Zipursky SL. A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains. Cell. 2007 Sep 21;130(6):1134-45.
• Hattori D, Demir E, Kim HW, Viragh E, Zipursky SL, Dickson BJ. Dscam diversity is essential for neuronal wiring and self-recognition. Nature. 2007 Sep 13;449(7159):223-7.
• Millard SS, Flanagan JJ, Pappu KS, Wu W, Zipursky SL. Dscam2 mediates axonal tiling in the Drosophila visual system. Nature. 2007 Jun 7;447(7145):720-4. PubMed PMID: 17554308; PubMed Central PMCID: PMC2691714.
• Matthews BJ, Kim ME, Flanagan JJ, Hattori D, Clemens JC, Zipursky SL, Grueber WB. Dendrite self-avoidance is controlled by Dscam. Cell. 2007 May 4;129(3):593-604.
• Zipursky SL, Wojtowicz WM, Hattori D. Got diversity? Wiring the fly brain with Dscam. Trends Biochem Sci. 2006 Oct;31(10):581-8. Epub 2006 Aug 21. Review.
• Zhu H, Hummel T, Clemens JC, Berdnik D, Zipursky SL, Luo L. Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe. Nat Neurosci. 2006 Mar;9(3):349-55. Epub 2006 Feb 12.
• Nern A, Nguyen LV, Herman T, Prakash S, Clandinin TR, Zipursky SL. An isoform-specific allele of Drosophila N-cadherin disrupts a late step of R7 targeting. Proc Natl Acad Sci U S A. 2005 Sep 6;102(36):12944-9. Epub 2005 Aug 25.
• Sang TK, Li C, Liu W, Rodriguez A, Abrams JM, Zipursky SL, Jackson GR. Inactivation of Drosophila Apaf-1 related killer suppresses formation of polyglutamine aggregates and blocks polyglutamine pathogenesis. Hum Mol Genet. 2005 Feb 1;14(3):357-72. Epub 2004 Dec 8.
• Graveley BR, Kaur A, Gunning D, Zipursky SL, Rowen L, Clemens JC. The organization and evolution of the dipteran and hymenopteran Down syndrome cell adhesion molecule (Dscam) genes. RNA. 2004 Oct;10(10):1499-506.
• Wojtowicz WM, Flanagan JJ, Millard SS, Zipursky SL, Clemens JC. Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell. 2004 Sep 3;118(5):619-33.
• Zhan XL, Clemens JC, Neves G, Hattori D, Flanagan JJ, Hummel T, Vasconcelos ML, Chess A, Zipursky SL. Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies. Neuron. 2004 Sep 2;43(5):673-86.
• Hummel T, Zipursky SL. Afferent induction of olfactory glomeruli requires N-cadherin. Neuron. 2004 Apr 8;42(1):77-88.
• Guo M, Hong EJ, Fernandes J, Zipursky SL, Hay BA. A reporter for amyloid precursor protein gamma-secretase activity in Drosophila. Hum Mol Genet. 2003 Oct 15;12(20):2669-78. Epub 2003 Aug 27.
• Lee RC, Clandinin TR, Lee CH, Chen PL, Meinertzhagen IA, Zipursky SL. The protocadherin Flamingo is required for axon target selection in the Drosophila visual system. Nat Neurosci. 2003 Jun;6(6):557-63.
• Hummel T, Vasconcelos ML, Clemens JC, Fishilevich Y, Vosshall LB, Zipursky SL. Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam. Neuron. 2003 Jan 23;37(2):221-31.
• Clandinin TR, Zipursky SL. Making connections in the fly visual system. Neuron. 2002 Aug 29;35(5):827-41. Review.
• Hummel T, Attix S, Gunning D, Zipursky SL. Temporal control of glial cell migration in the Drosophila eye requires gilgamesh, hedgehog, and eye specification genes. Neuron. 2002 Jan 17;33(2):193-203.
• Suh GS, Poeck B, Chouard T, Oron E, Segal D, Chamovitz DA, Zipursky SL. Drosophila JAB1/CSN5 acts in photoreceptor cells to induce glial cells. Neuron. 2002 Jan 3;33(1):35-46.
• Clandinin TR, Lee CH, Herman T, Lee RC, Yang AY, Ovasapyan S, Zipursky SL. Drosophila LAR regulates R1-R6 and R7 target specificity in the visual system. Neuron. 2001 Oct 25;32(2):237-48.
• Lee CH, Herman T, Clandinin TR, Lee R, Zipursky SL. N-cadherin regulates target specificity in the Drosophila visual system. Neuron. 2001 May;30(2):437-50.
• Poeck B, Fischer S, Gunning D, Zipursky SL, Salecker I. Glial cells mediate target layer selection of retinal axons in the developing visual system of Drosophila. Neuron. 2001 Jan;29(1):99-113.
• Clandinin TR, Zipursky SL. Afferent growth cone interactions control synaptic specificity in the Drosophila visual system. Neuron. 2000 Nov;28(2):427-36.
• Schmucker D, Clemens JC, Shu H, Worby CA, Xiao J, Muda M, Dixon JE, Zipursky SL. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell. 2000 Jun 9;101(6):671-84.
• Rao Y, Pang P, Ruan W, Gunning D, Zipursky SL. brakeless is required for photoreceptor growth-cone targeting in Drosophila. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5966-71.
• Hing H, Xiao J, Harden N, Lim L, Zipursky SL. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Cell. 1999 Jun 25;97(7):853-63
• Garrity PA, Lee CH, Salecker I, Robertson HC, Desai CJ, Zinn K, Zipursky SL. Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase. Neuron. 1999 Apr;22(4):707-17.
• Jackson GR, Salecker I, Dong X, Yao X, Arnheim N, Faber PW, MacDonald ME, Zipursky SL. Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron. 1998 Sep;21(3):633-42.
• Rao Y, Zipursky SL. Domain requirements for the Dock adapter protein in growth- cone signaling. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2077-82.
• Garrity PA, Rao Y, Salecker I, McGlade J, Pawson T, Zipursky SL. Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein. Cell. 1996 May 31;85(5):639-50.